How to replace all occurrences of a string except the first one in JavaScript?

You can pass a function to String#replace, where you can specify to omit replacing the first occurrence. Also make your first parameter of replace a regex to match all occurrences.

Demo

let str = 'hello world hello world hello world hello',
    i = 0;
    
str = str.replace(/world/g, m  => !i++ ? m : '');
console.log(str);

Note

You could avoid using the global counter variable i by using a IIFE:

let str = 'hello world hello world hello world hello';

str = str.replace(/world/g, (i => m => !i++ ? m : '')(0));
console.log(str);

var str = 'hello world hello world hello world hello'; 

var count = 0;
var result = str.replace(/world/gi, function (x) {
  if(count == 0) {
      count++;
      return x;
    } else {
      return '';	
    }
});

console.log(result);

In my solution, I am replacing first occurrence with a current timestamp, then replacing all occurrences and then finally replacing timestamp with world

You can also use str.split('world') and then join

var str = 'hello world hello world hello world hello';
var strs = str.split('world');
str = strs[0] + 'world' + strs.slice(1).join('');
console.log(str);

var str = 'hello world hello world hello world hello';

const d = Date.now()
str = str.replace('world', d).replace(/world/gi, '').replace(d, 'world');

console.log(str);

To provide an alternative to @Kristianmitk excellent answer, we can use a positive lookbehind, which is supported in Node.Js & Chrome >= 62

const string = 'hello world hello world hello world hello';

console.log(
  string.replace(/(?<=world[\s\S]+)world/g, '')
);
// or
console.log(
  string.replace(/(?<=(world)[\s\S]+)\1/g, '')
);

Using Symbol.replace well-known symbol.

The Symbol.replace well-known symbol specifies the method that replaces matched substrings of a string. This function is called by the String.prototype.replace() method.

const string = 'hello world hello world hello world hello';

class ReplaceButFirst {
     constructor(word, replace = '') {
         this.count = 0;
         this.replace = replace;
         this.pattern = new RegExp(word, 'g');
     }
     
     [Symbol.replace](str) {
          return str.replace(this.pattern, m => !this.count++ ? m : this.replace);
     }
}

console.log(
  string.replace(new ReplaceButFirst('world'))
);