tmux set -g mouse-mode on doesn't work

So this option has been renamed in version 2.1 (18 October 2015)

From the changelog:

 Mouse-mode has been rewritten.  There's now no longer options for:
    - mouse-resize-pane
    - mouse-select-pane
    - mouse-select-window
    - mode-mouse

  Instead there is just one option:  'mouse' which turns on mouse support

So this is what I'm using now in my .tmux.conf file

set -g mouse on

As @Graham42 noted, mouse option has changed in version 2.1. Scrolling now requires for you to enter copy mode first. To enable scrolling almost identical to how it was before 2.1 add following to your .tmux.conf.

set-option -g mouse on

# make scrolling with wheels work
bind -n WheelUpPane if-shell -F -t = "#{mouse_any_flag}" "send-keys -M" "if -Ft= '#{pane_in_mode}' 'send-keys -M' 'select-pane -t=; copy-mode -e; send-keys -M'"
bind -n WheelDownPane select-pane -t= \; send-keys -M

This will enable scrolling on hover over a pane and you will be able to scroll that pane line by line.

Source: https://groups.google.com/d/msg/tmux-users/TRwPgEOVqho/Ck_oth_SDgAJ

Just a quick heads-up to anyone else who is losing their mind right now:

https://github.com/tmux/tmux/blob/310f0a960ca64fa3809545badc629c0c166c6cd2/CHANGES#L12

so that's just

 :setw -g mouse