Strip double quotes from a string in .NET

I think your first line would actually work but I think you need four quotation marks for a string containing a single one (in VB at least):

s = s.Replace("""", "")

for C# you'd have to escape the quotation mark using a backslash:

s = s.Replace("\"", "");

I didn't see my thoughts repeated already, so I will suggest that you look at string.Trim in the Microsoft documentation for C# you can add a character to be trimmed instead of simply trimming empty spaces:

string withQuotes = "\"hellow\"";
string withOutQotes = withQuotes.Trim('"');

should result in withOutQuotes being "hello" instead of ""hello""