Specify path of savefig with pylab or matplotlib

For matplotlib.pyplot, the error FileNotFoundError: [Errno 2] No such file or directory can occur due to nonexistence of the containing folder ../MyDocs/resource/frames/. So maybe first create the folder

import os
os.makedirs('../MyDocs/resource/frames/')

then rerun the savefig function.

The tilde operator and the variable $HOME are entered as strings and therefore do not function while saving. You have to provide either relative path (as you did) or provide the full path. Eg. pylab.savefig("/home/username/Desktop/myfig.png").