Run batch script before Debugging

You can use a VS macro.

I had the same issue and this is the best I came with so far

Dim MustUpdateDB As Boolean

    Private Sub DebuggerEvents_OnEnterRunMode(ByVal Reason As EnvDTE.dbgEventReason) Handles DebuggerEvents.OnEnterRunMode
        If (MustUpdateDB) Then
            MsgBox("Start debug operation", MsgBoxStyle.OkOnly, "TITLE")
            REM DO WHATEVER COMMAND HERE
            REM  System.Diagnostics.Process.Start("C:\listfiles.bat")
            MustUpdateDB = False
        End If


    End Sub

    Private Sub BuildEvents_OnBuildDone(ByVal Scope As EnvDTE.vsBuildScope, ByVal Action As EnvDTE.vsBuildAction) Handles BuildEvents.OnBuildDone
        MsgBox("Build Done", MsgBoxStyle.OkOnly, "Title")
        MustUpdateDB = True
    End Sub

There is a pretty good explanation on how to add event handlers to a macro here

The only issue I have so far is to figure out how to get the currently debugged application active directory

I realise you wished to avoid additional code, but in your Main function you could use Debugger.IsAttached() to kick off your work for you.

For example:

if (Debugger.IsAttached)
{
     System.Diagnostics.Process.Start(@"C:\myBatchFile.bat");
}