Replace the string of special characters in C#

I believe, best is to use a regular expression here as below

s/[*'",_&#^@]/ /g

You can use Regex class for this purpose

Regex reg = new Regex("[*'\",_&#^@]");
str1 = reg.Replace(str1, string.Empty);

Regex reg1 = new Regex("[ ]");
str1 = reg.Replace(str1, "-");

Use Regular Expression

Regex.Replace("Hello*Hello'Hello&Hello@Hello Hello", @"[^0-9A-Za-z ,]", "").Replace(" ", "-")

It will replace all special characters with string.Empty and Space with "-"

Make a collection of changes to make and iterate over it:

var replacements = new []
                   { new { Old = "*", New = string.Empty }
                   // all your other replacements, removed for brevity
                   , new { Old = " ", New = "-" }
                   }

foreach (var r in replacements)
{
    Charseparated = Charseparated.Replace(r.Old, r.New);
}