ReactJs: Prevent multiple times button press

The solution is to check the state immediately upon entry to the handler. React guarantees that setState inside interactive events (such as click) is flushed at browser event boundary. Ref: https://github.com/facebook/react/issues/11171#issuecomment-357945371

// In constructor
this.state = {
    disabled : false
};


// Handler for on click
handleClick = (event) => {
    if (this.state.disabled) {
        return;
    }
    this.setState({disabled: true});
    // Send     
}

// In render
<button onClick={this.handleClick} disabled={this.state.disabled} ...>
    {this.state.disabled ? 'Sending...' : 'Send'}
<button>

What you could do is make the button disabled after is clicked and leave it in the page (not clickable element).

To achieve this you have to add a ref to the button element

<button ref="btn" onClick={this.onClickUploadFile}>Send</button>

and then on the onClickUploadFile function disable the button

this.refs.btn.setAttribute("disabled", "disabled");

You can then style the disabled button accordingly to give some feedback to the user with

.btn:disabled{ /* styles go here */}

If needed make sure to reenable it with

this.refs.btn.removeAttribute("disabled");

Update: the preferred way of handling refs in React is with a function and not a string.

<button 
  ref={btn => { this.btn = btn; }} 
  onClick={this.onClickUploadFile}
>Send</button>


this.btn.setAttribute("disabled", "disabled");
this.btn.removeAttribute("disabled");

Update: Using react hooks

import {useRef} from 'react';
let btnRef = useRef();

const onBtnClick = e => {
  if(btnRef.current){
    btnRef.current.setAttribute("disabled", "disabled");
  }
}

<button ref={btnRef} onClick={onBtnClick}>Send</button>

here is a small example using the code you provided https://jsfiddle.net/69z2wepo/30824/