React.js throttle mousemove event keep throwing event.persist() error

e.persist needs to be called synchronously with the event, the handler can be called asynchronously. Here is a fix:

class Tool extends React.Component {
  constructor(props) {
    super(props);
    this._throttledMouseMove = _.throttle(this._throttledMouseMove.bind(this), 2000);
  }

  _throttledMouseMove = (e) => {
    console.log(e.screenX);
  }

  render() {    
    return (
      <div ref="tool" className="tool">
        <div ref="toolBody"
             className="tool__body"
             onMouseMove={this._onMouseMove}>
        </div>
      </div>
    )
  }

  _onMouseMove = (e) => {
    e.persist();
    this._throttledMouseMove(e);

  }
}
ReactDOM.render(<Tool/>, document.querySelector('.main'))

The relevant change is calling _onMouseMove directly from the event, and setting up a second method to actually handle event that's been throttled.

With hooks:

const Tool = () => {
  const onMouseMove = useMemo(() => {
    const throttled = _.throttle(e => console.log(e.screenX), 300);
    return e => {
      e.persist();
      return throttled(e);
    };
  }, []);
  return (
    <div className="tool">
      <div className="tool__body" onMouseMove={onMouseMove}>
        Content
      </div>
    </div>
  );
};