Mouse stopped clicking in CentOS running in Virtual Box

After a more recent update problem goes away. First known by me kernel version where the problem has gone:

Linux centos7 3.10.0-957.10.1.el7.x86_64 #1 SMP Mon Mar 18 15:06:45 UTC 2019 x86_64 x86_64 x86_64  GNU/Linux

I have the similar issue with Centos 7.4 on VirtualBox 5 recently.

Once I left-click and start working on an application, I could not left-click on any other part nor applications to switch the focus.

My work-around is to right click the mouse on the stuck application twice. A context menu will pop up and go away. Then I can left-click any other parts of the desktop. Of course, doing this every time when one wants to switch the focus is still annoying but at least workable.