Merging non-overlapping array blocks

Use transpose/swapaxes to swap the second and third axes and then reshape to have the last two axes merged -

B.transpose(0,2,1,3).reshape(-1,B.shape[1]*B.shape[3])
B.swapaxes(1,2).reshape(-1,B.shape[1]*B.shape[3])

Sample run -

In [41]: A
Out[41]: 
array([[ 0,  1,  2,  3],
       [ 4,  5,  6,  7],
       [ 8,  9, 10, 11],
       [12, 13, 14, 15]])

In [42]: B = view_as_blocks(A, block_shape=(2, 2))

In [43]: B
Out[43]: 
array([[[[ 0,  1],
         [ 4,  5]],

        [[ 2,  3],
         [ 6,  7]]],


       [[[ 8,  9],
         [12, 13]],

        [[10, 11],
         [14, 15]]]])

In [44]: B.transpose(0,2,1,3).reshape(-1,B.shape[1]*B.shape[3])
Out[44]: 
array([[ 0,  1,  2,  3],
       [ 4,  5,  6,  7],
       [ 8,  9, 10, 11],
       [12, 13, 14, 15]])