Keyboard shortcuts are not active in Visual Studio with Resharper installed
I would first try resetting all Visual Studio settings (Tools > Import and Export Settings > Reset all settings), then go to the Resharper > Options > Keyboard & Menus and re-apply the keyboard shortcut scheme.
I had to do something similar once.
This worked for me.
Setting to Resharper / Options / KeyBoard & Menus / None / Apply and Save
Resharper / Options / KeyBoard & Menus / Set to Visual Studio / Apply and Save