Is there a gui application for managing multiple mice/keyboards?

9.04 only

Roland, regarding your query Its was very much possible using a tool called

gnome-device-setup

I used it myself on 9.04

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You can see it in action http://www.youtube.com/watch?v=nS06QjHlrwk&feature=related

Sadly, the links are broken http://people.freedesktop.org/~whot/gnome-device-setup

This has been taken from http://who-t.blogspot.com/2008/07/gnome-device-setup.html

the gnome-device-setup seems to me like a frontend to xinput. With these commands you are able to create more virtual pointers:

xinput list
xinput create-master <name>
xinput reattach <input-id> <pointer-id>  (id you can get from xinput list)

have fun.