Is there a feasible way to trigger CSS keyframe animation using JS?

see here jsfiddle

if you want your animation to work every time you press the button use this code :

$('button').click(function() {
    $(".fademe").addClass('animated');
    setTimeout(function() {
      $(".fademe").removeClass('animated');
    }, 1500);
});

where 1500 is the animation-duration in this case, 1.5s

$('button').click(function() {
  $(".fademe").addClass('animated');
  setTimeout(function() {
    $(".fademe").removeClass('animated');
  }, 1500);
});
.fademe {
  width: 100px;
  height: 100px;
  background: red;
}

.fademe.animated {
  animation: fade-in 1.5s ease;
}


@keyframes fade-in {
  0% {
    opacity: 0;
  }

  100% {
    opacity: 1;
  }
}
<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.3.1/jquery.min.js"></script>
<div class="fademe">

</div>

<button>CLICK ME</button>

EXPLANATION :

  1. on click on the button add class animated ( or any other class ) to the element you want to apply the animation to , .fademe
  2. make a setTimeout(function() to delay the removeClass for the duration of the animation 1.5s or 1500ms
  3. write in CSS the declaration of the animation , @keyframes, and add it to the element with the class added by the JQ .fademe.animated

$("#move-button").on("click", function(){
  $("#ship").removeClass("moving");
  $("#ship")[0].offsetWidth = $("#ship")[0].offsetWidth;
  $("#ship").addClass("moving");
});//
#ship
{
  background: green;
  color: #fff;
  height: 60px;
  line-height: 60px;
  text-align: center;
  width: 100px;
}

#move-button
{
  margin-top: 20px;
}

#ship.moving
{
  animation: moving 2s ease;
}

@keyframes moving
{
  0%{ transform: translate(0px);}
  50%{ transform: translate(20px);}
  100%{ transform: translate(0px);}
}
<script src="https://ajax.googleapis.com/ajax/libs/jquery/1.11.1/jquery.min.js"></script>
<div id="ship">Ship</div>
<button id="move-button">Push</button>