Is it safe to purge %WinDir%\assembly\NativeImages*\Temp\?

it certainly isn't normal behaviour. something must have gone wrong.
i have checked multiple machines. including different windows versions. most of them do not show these symptoms.

after doing some more searching i ran across a discussion thread (in german language) here: http://www.mcseboard.de/topic/210325-exchange-m%C3%BCllt-c-zu/

there the OP mentions a particular antivirus software by "g data".
and yes, on all of my machines that are showing these symptoms i have also installed this antivirus software. either the personal edition "g data antivirus 25.3.0.3" or the "business" edition "14.0.1.122".

so far i have confirmed this symptom on: windows 7, windows 10, windows 2008 r2.
i have also tested and reproduced the symptom on a "clean" machine: the temp folders are empty. then i installed this antivirus software. once i install some updates for the .net framework it is now leaking files in the NativeImages temp folders.

i had opened a support ticket with the vendor.
the support team has confirmed they already know about this issue and that they're working on a fix for both, the business and the personal edition of their antivirus software.
they have not come back with a clear answer weather it's safe to manually delete the leaked files.

anyways, i have manually emptied those folders and have not faced any issues so far.