How to use if within a map return?

You put return statement inside if clause like so:

    row = this.props.cells.map(function(cell, i) {

        if(cell.URL != null && cell.URL.length > 0){
            return <td className={cell.Meta.HTMLClass} key={i}>{cell.Text}</td>;        
        }
        else {
            return <td className={cell.Meta.HTMLClass} key={i}>{cell.Text}</td>;
        }

    }.bind(this));

You could also use a ternary (inline if/else) statement. It might look like this:

row = this.props.cells.map(function(cell, i) {
    return (cell.URL != null && cell.URL.length > 0) ? 
        (<td className={cell.Meta.HTMLClass} key={i}>{cell.Text}</td>) :
        (<td className={cell.Meta.HTMLClass} key={i}>{cell.Text}</td>)
}.bind(this));

or es6

row = this.props.cells.map((cell, i) => (cell.URL != null && cell.URL.length > 0) ? 
        (<td className={cell.Meta.HTMLClass} key={i}>{cell.Text}</td>) :
        (<td className={cell.Meta.HTMLClass} key={i}>{cell.Text}</td>)
);

but, for readability, I would suggest nilgun's answer.

Although I would remove the else statement, since it is redundant. You could also remove the curly brackets, this is a matter of preference.

row = this.props.cells.map(function(cell, i) {
    if(cell.URL != null && cell.URL.length > 0)
        return <td className={cell.Meta.HTMLClass} key={i}>{cell.Text}</td>;        
    return <td className={cell.Meta.HTMLClass} key={i}>{cell.Text}</td>;
}.bind(this));