How to specify different match patterns for multiple content scripts in the manifest.json file of the same extension

Specifying the content_scripts within manifest.json is a bit limiting. Although you can specify different match patterns, you can only have it execute one possible slew of files.

To achieve what you want, you'll need to set up a background_page that can interpret page URLs, and execute content scripts as you see fit.

Three different methods might be:

1. Use the manifest's content_scripts to match all possible URLs and execute a simple content script to send a message request to the background page via chrome.extension.sendRequest(). The background page listens for messages with chrome.extension.onRequest.addListener(), receives the message, interprets the tab's URL with sender.tab.url (or have the tab's message send window.location.hostname, probably easier), then decides what content scripts to inject to the tab via chrome.tabs.executeScript().
    
   or

2. Just have your background_page listen for chrome.tabs.onCreated.addListener() and chrome.tabs.onUpdated.addListener() to get a tab's URL, then decide what content scripts to inject to the tab via chrome.tabs.executeScript(). No need to specify content_scripts in the manifest for this.  
    
   or

3. Similar to 1, but have your manifest content_scripts script figure out what to do based on the current URL (again could interpret window.location.hostname), then use chrome.extension.sendRequest() with a message for your background_page stating which content scripts to execute (meaning your background_page doesn't decide - the original content script does). Same result though.