How to reload a page in Opera without cache?

Upgrade to Opera 11.62 which was released a day ago. From the changelog:

Support Ctrl+F5 and Shift+F5 for unconditional reload of web page (bypass cache)

Opera

Use one of the following:

Hold the Ctrl key and press the F5 key.

Hold the ⇧ Shift key and press the F5 key.

Hold the Ctrl key and click the Reload button on the navigation toolbar.

Hold the ⇧ Shift key and click the Reload button on the navigation toolbar.

Internet Explorer

Use one of the following:

Hold the Ctrl key and press the F5 key.

Hold the Ctrl key and click the "Refresh" button on the toolbar.

Google Chrome

On Windows, use one of the following:

Hold the Ctrl key and press the F5 key.

Hold the ⇧ Shift key and press the F5 key.

Hold the Ctrl key and click the Reload button on the navigation toolbar.

Hold the ⇧ Shift key and click the Reload button on the navigation toolbar.

On Mac OS X:

Hold both the ⌘ Cmd and ⇧ Shift keys and press the R key.

On Linux:

Hold the Ctrl key and press the F5 key.

Firefox and other related browsers

These instructions work for Firefox, SeaMonkey, and other related browsers.

On Windows and Linux, use one of the following:

Hold both the Ctrl and ⇧ Shift keys and then press R.

Hold the ⇧ Shift key and click the Reload button on the navigation toolbar.

Hold the Ctrl key and press the F5 key.

On Mac OS X, use one of the following:

Hold both the ⌘ Cmd and ⇧ Shift keys and then press R.

Hold the ⇧ Shift key and click the Reload button on the navigation toolbar.

Safari

For version 4 and newer:

Hold down the ⇧ Shift key and click the Reload toolbar button.

For version 3 and older:

Hold down the ⌘ Cmd key and press R.  This kind of "regular" reload will usually bypass the cache.

Note  that  Apple  claims  that  clicking  the  "Reload"  toolbar  button  has  the  same  effect  as  ⌘ Cmd+R, but this is not true; frequently the button will not bypass the cache.

Konqueror

Press F5 or click the "Reload" button on the toolbar.

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Bypassing cache