How to prevent file redirection to VirtualStore for read/write files?

First, ask yourself, do this need to be globally saved for all users?

If it doesn't have to be, save the file in Application Data instead, you can get the path with Environment.GetFolderPath(Environment.SpecialFolder.ApplicationData), it should always reliably expand to C:\Users\Username\AppData\Roaming\. Do note that this path is unique for each user though.

If you have to, you're out of luck. There is no reliable way to store application data for all users without admin rights (or UAC) on any Windows post-XP that's not extremely hacky, like storing your data in the Public user (which may or may not be possible, I can't check right now).