How to modify grid-template-areas with javascript

Your elem.style.gridTemplateAreas = "z z z" "a b c" "d e f"

Is not a valid statement or it does not do what you want to do. You want to assign the value "z z z" "a b c" "d e f". Therefore, you need to surround it by quotes like this: elem.style.gridTemplateAreas = '"z z z" "a b c" "d e f"';

window.addEventListener("click", function(){
	let elem= document.getElementById("grid");
	elem.style.gridTemplateAreas = '"z z z" "a b c" "d e f"';

  	console.log("The grid-template area should have been redefined now. The blue block should have move to the top row.");
});
#grid{
  width: 100px;
  height: 100px;
  background-color: red;
  display: grid;
  grid-template-columns: 1fr 1fr 1fr;
  grid-template-rows: 1fr 1fr 1fr;
  grid-template-areas:  "x x x"
                        "y y z"
                        "y y z";
}
#div1{
  background-color: blue;
  grid-area: z;
}
<h3>Click to activate the code</h3>
<div id="grid">
<div id="div1"></div>
</div>

just change to elem.style.gridTemplateAreas ='"z z z" "a b c" "d e f"';