How to enable Pan and Zoom in a QGraphicsView

This is not too difficult to do using the built in capabilities of QGraphicsView.

The demo script below has left-button panning and wheel zoom (including anchoring to the current cursor position). The fitInView method has been reimplemented because the built in version adds a weird fixed margin that can't be removed.

PyQt4 version:

from PyQt4 import QtCore, QtGui

class PhotoViewer(QtGui.QGraphicsView):
    photoClicked = QtCore.pyqtSignal(QtCore.QPoint)

    def __init__(self, parent):
        super(PhotoViewer, self).__init__(parent)
        self._zoom = 0
        self._empty = True
        self._scene = QtGui.QGraphicsScene(self)
        self._photo = QtGui.QGraphicsPixmapItem()
        self._scene.addItem(self._photo)
        self.setScene(self._scene)
        self.setTransformationAnchor(QtGui.QGraphicsView.AnchorUnderMouse)
        self.setResizeAnchor(QtGui.QGraphicsView.AnchorUnderMouse)
        self.setVerticalScrollBarPolicy(QtCore.Qt.ScrollBarAlwaysOff)
        self.setHorizontalScrollBarPolicy(QtCore.Qt.ScrollBarAlwaysOff)
        self.setBackgroundBrush(QtGui.QBrush(QtGui.QColor(30, 30, 30)))
        self.setFrameShape(QtGui.QFrame.NoFrame)

    def hasPhoto(self):
        return not self._empty

    def fitInView(self, scale=True):
        rect = QtCore.QRectF(self._photo.pixmap().rect())
        if not rect.isNull():
            self.setSceneRect(rect)
            if self.hasPhoto():
                unity = self.transform().mapRect(QtCore.QRectF(0, 0, 1, 1))
                self.scale(1 / unity.width(), 1 / unity.height())
                viewrect = self.viewport().rect()
                scenerect = self.transform().mapRect(rect)
                factor = min(viewrect.width() / scenerect.width(),
                             viewrect.height() / scenerect.height())
                self.scale(factor, factor)
            self._zoom = 0

    def setPhoto(self, pixmap=None):
        self._zoom = 0
        if pixmap and not pixmap.isNull():
            self._empty = False
            self.setDragMode(QtGui.QGraphicsView.ScrollHandDrag)
            self._photo.setPixmap(pixmap)
        else:
            self._empty = True
            self.setDragMode(QtGui.QGraphicsView.NoDrag)
            self._photo.setPixmap(QtGui.QPixmap())
        self.fitInView()

    def wheelEvent(self, event):
        if self.hasPhoto():
            if event.delta() > 0:
                factor = 1.25
                self._zoom += 1
            else:
                factor = 0.8
                self._zoom -= 1
            if self._zoom > 0:
                self.scale(factor, factor)
            elif self._zoom == 0:
                self.fitInView()
            else:
                self._zoom = 0

    def toggleDragMode(self):
        if self.dragMode() == QtGui.QGraphicsView.ScrollHandDrag:
            self.setDragMode(QtGui.QGraphicsView.NoDrag)
        elif not self._photo.pixmap().isNull():
            self.setDragMode(QtGui.QGraphicsView.ScrollHandDrag)

    def mousePressEvent(self, event):
        if self._photo.isUnderMouse():
            self.photoClicked.emit(self.mapToScene(event.pos()).toPoint())
        super(PhotoViewer, self).mousePressEvent(event)


class Window(QtGui.QWidget):
    def __init__(self):
        super(Window, self).__init__()
        self.viewer = PhotoViewer(self)
        # 'Load image' button
        self.btnLoad = QtGui.QToolButton(self)
        self.btnLoad.setText('Load image')
        self.btnLoad.clicked.connect(self.loadImage)
        # Button to change from drag/pan to getting pixel info
        self.btnPixInfo = QtGui.QToolButton(self)
        self.btnPixInfo.setText('Enter pixel info mode')
        self.btnPixInfo.clicked.connect(self.pixInfo)
        self.editPixInfo = QtGui.QLineEdit(self)
        self.editPixInfo.setReadOnly(True)
        self.viewer.photoClicked.connect(self.photoClicked)
        # Arrange layout
        VBlayout = QtGui.QVBoxLayout(self)
        VBlayout.addWidget(self.viewer)
        HBlayout = QtGui.QHBoxLayout()
        HBlayout.setAlignment(QtCore.Qt.AlignLeft)
        HBlayout.addWidget(self.btnLoad)
        HBlayout.addWidget(self.btnPixInfo)
        HBlayout.addWidget(self.editPixInfo)
        VBlayout.addLayout(HBlayout)

    def loadImage(self):
        self.viewer.setPhoto(QtGui.QPixmap('image.jpg'))

    def pixInfo(self):
        self.viewer.toggleDragMode()

    def photoClicked(self, pos):
        if self.viewer.dragMode()  == QtGui.QGraphicsView.NoDrag:
            self.editPixInfo.setText('%d, %d' % (pos.x(), pos.y()))


if __name__ == '__main__':
    import sys
    app = QtGui.QApplication(sys.argv)
    window = Window()
    window.setGeometry(500, 300, 800, 600)
    window.show()
    sys.exit(app.exec_())

PyQt5 version:

from PyQt5 import QtCore, QtGui, QtWidgets

class PhotoViewer(QtWidgets.QGraphicsView):
    photoClicked = QtCore.pyqtSignal(QtCore.QPoint)

    def __init__(self, parent):
        super(PhotoViewer, self).__init__(parent)
        self._zoom = 0
        self._empty = True
        self._scene = QtWidgets.QGraphicsScene(self)
        self._photo = QtWidgets.QGraphicsPixmapItem()
        self._scene.addItem(self._photo)
        self.setScene(self._scene)
        self.setTransformationAnchor(QtWidgets.QGraphicsView.AnchorUnderMouse)
        self.setResizeAnchor(QtWidgets.QGraphicsView.AnchorUnderMouse)
        self.setVerticalScrollBarPolicy(QtCore.Qt.ScrollBarAlwaysOff)
        self.setHorizontalScrollBarPolicy(QtCore.Qt.ScrollBarAlwaysOff)
        self.setBackgroundBrush(QtGui.QBrush(QtGui.QColor(30, 30, 30)))
        self.setFrameShape(QtWidgets.QFrame.NoFrame)

    def hasPhoto(self):
        return not self._empty

    def fitInView(self, scale=True):
        rect = QtCore.QRectF(self._photo.pixmap().rect())
        if not rect.isNull():
            self.setSceneRect(rect)
            if self.hasPhoto():
                unity = self.transform().mapRect(QtCore.QRectF(0, 0, 1, 1))
                self.scale(1 / unity.width(), 1 / unity.height())
                viewrect = self.viewport().rect()
                scenerect = self.transform().mapRect(rect)
                factor = min(viewrect.width() / scenerect.width(),
                             viewrect.height() / scenerect.height())
                self.scale(factor, factor)
            self._zoom = 0

    def setPhoto(self, pixmap=None):
        self._zoom = 0
        if pixmap and not pixmap.isNull():
            self._empty = False
            self.setDragMode(QtWidgets.QGraphicsView.ScrollHandDrag)
            self._photo.setPixmap(pixmap)
        else:
            self._empty = True
            self.setDragMode(QtWidgets.QGraphicsView.NoDrag)
            self._photo.setPixmap(QtGui.QPixmap())
        self.fitInView()

    def wheelEvent(self, event):
        if self.hasPhoto():
            if event.angleDelta().y() > 0:
                factor = 1.25
                self._zoom += 1
            else:
                factor = 0.8
                self._zoom -= 1
            if self._zoom > 0:
                self.scale(factor, factor)
            elif self._zoom == 0:
                self.fitInView()
            else:
                self._zoom = 0

    def toggleDragMode(self):
        if self.dragMode() == QtWidgets.QGraphicsView.ScrollHandDrag:
            self.setDragMode(QtWidgets.QGraphicsView.NoDrag)
        elif not self._photo.pixmap().isNull():
            self.setDragMode(QtWidgets.QGraphicsView.ScrollHandDrag)

    def mousePressEvent(self, event):
        if self._photo.isUnderMouse():
            self.photoClicked.emit(self.mapToScene(event.pos()).toPoint())
        super(PhotoViewer, self).mousePressEvent(event)


class Window(QtWidgets.QWidget):
    def __init__(self):
        super(Window, self).__init__()
        self.viewer = PhotoViewer(self)
        # 'Load image' button
        self.btnLoad = QtWidgets.QToolButton(self)
        self.btnLoad.setText('Load image')
        self.btnLoad.clicked.connect(self.loadImage)
        # Button to change from drag/pan to getting pixel info
        self.btnPixInfo = QtWidgets.QToolButton(self)
        self.btnPixInfo.setText('Enter pixel info mode')
        self.btnPixInfo.clicked.connect(self.pixInfo)
        self.editPixInfo = QtWidgets.QLineEdit(self)
        self.editPixInfo.setReadOnly(True)
        self.viewer.photoClicked.connect(self.photoClicked)
        # Arrange layout
        VBlayout = QtWidgets.QVBoxLayout(self)
        VBlayout.addWidget(self.viewer)
        HBlayout = QtWidgets.QHBoxLayout()
        HBlayout.setAlignment(QtCore.Qt.AlignLeft)
        HBlayout.addWidget(self.btnLoad)
        HBlayout.addWidget(self.btnPixInfo)
        HBlayout.addWidget(self.editPixInfo)
        VBlayout.addLayout(HBlayout)

    def loadImage(self):
        self.viewer.setPhoto(QtGui.QPixmap('image.jpg'))

    def pixInfo(self):
        self.viewer.toggleDragMode()

    def photoClicked(self, pos):
        if self.viewer.dragMode()  == QtWidgets.QGraphicsView.NoDrag:
            self.editPixInfo.setText('%d, %d' % (pos.x(), pos.y()))


if __name__ == '__main__':
    import sys
    app = QtWidgets.QApplication(sys.argv)
    window = Window()
    window.setGeometry(500, 300, 800, 600)
    window.show()
    sys.exit(app.exec_())

It is possible to open TIFF files up to several gigabytes with ordinary PIL (pillow) library. It is not quite easy, but it works.

You could see the example here, second example after bold EDIT string could open, move and zoom TIFF files.