How to create a function at runtime with specified argument names?

Here's a somewhat hacky way to do it which first creates a new function from an existing one with the modification and then replaces the original's code with it. It's lengthly mostly because the types.CodeType() call has so many arguments. The Python 3 version is somewhat different because a number of the function.func_code attributes were renamed and the calling sequence of types.CodeType() was changed slightly.

I got the idea from this answer by @aaronasterling (who says he got the idea from Michael Foord's Voidspace blog entry #583 titled Selfless Python). It could easily be made into a decorator, but I don't see that as being helpful based on what you've told us of the intended usage.

import sys
import types

def change_func_args(function, new_args):
    """ Create a new function with its arguments renamed to new_args. """

    if sys.version_info[0] < 3:  # Python 2?
        code_obj = function.func_code
        assert(0 <= len(new_args) <= code_obj.co_argcount)
        # The arguments are just the first co_argcount co_varnames.
        # Rreplace them with the new argument names in new_args.
        new_varnames = tuple(new_args[:code_obj.co_argcount] +
                             list(code_obj.co_varnames[code_obj.co_argcount:]))
        new_code_obj = types.CodeType(code_obj.co_argcount,
                                      code_obj.co_nlocals,
                                      code_obj.co_stacksize,
                                      code_obj.co_flags,
                                      code_obj.co_code,
                                      code_obj.co_consts,
                                      code_obj.co_names,
                                      new_varnames,
                                      code_obj.co_filename,
                                      code_obj.co_name,
                                      code_obj.co_firstlineno,
                                      code_obj.co_lnotab,
                                      code_obj.co_freevars,
                                      code_obj.co_cellvars)
        modified = types.FunctionType(new_code_obj, function.func_globals)

    else:  # Python 3
        code_obj = function.__code__
        assert(0 <= len(new_args) <= code_obj.co_argcount)
        # The arguments are just the first co_argcount co_varnames.
        # Replace them with the new argument names in new_args.
        new_varnames = tuple(new_args[:code_obj.co_argcount] +
                             list(code_obj.co_varnames[code_obj.co_argcount:]))

        new_code_obj = types.CodeType(code_obj.co_argcount,
                                      code_obj.co_posonlyargcount,
                                      code_obj.co_kwonlyargcount,
                                      code_obj.co_nlocals,
                                      code_obj.co_stacksize,
                                      code_obj.co_flags,
                                      code_obj.co_code,
                                      code_obj.co_consts,
                                      code_obj.co_names,
                                      new_varnames,
                                      code_obj.co_filename,
                                      code_obj.co_name,
                                      code_obj.co_firstlineno,
                                      code_obj.co_lnotab)

        modified = types.FunctionType(new_code_obj, function.__globals__)

    function.__code__ = modified.__code__  # replace code portion of original

if __name__ == '__main__':

    import inspect

    def f(x, y):
        return x+y

    def g(a, b):
        return f(a, b)

    print('Before:')
    print('inspect.getargspec(g).args: {}'.format(inspect.getargspec(g).args))
    print('g(1, 2): {}'.format(g(1, 2)))

    change_func_args(g, ['p', 'q'])

    print('')
    print('After:')
    print('inspect.getargspec(g).args: {}'.format(inspect.getargspec(g).args))
    print('g(1, 2): {}'.format(g(1, 2)))

I have a feeling you want something like this:

import inspect
import math

def multiply(x, y):
    return x * y

def add(a, b):
    return a + b

def cube(x):
    return x**3

def pythagorean_theorum(a, b, c):
    return math.sqrt(a**2 + b**2 + c**2)

def rpc_command(fname, *args, **kwargs):
    # Get function by name
    f = globals().get(fname)
    # Make sure function exists
    if not f:
        raise NotImplementedError("function not found: %s" % fname)
    # Make a dict of argname: argvalue
    arg_names = inspect.getargspec(f).args
    f_kwargs = dict(zip(arg_names, args))
    # Add kwargs to the function's kwargs
    f_kwargs.update(kwargs)
    return f(**f_kwargs)

Usage:

>>> # Positional args
... rpc_command('add', 1, 2)
3
>>> 
>>> # Keyword args
... rpc_command('multiply', x=20, y=6)
120
>>> # Keyword args passed as kwargs
... rpc_command('add', **{"a": 1, "b": 2})
3
>>> 
>>> # Mixed args
... rpc_command('multiply', 5, y=6)
30
>>> 
>>> # Different arg lengths
... rpc_command('cube', 3)
27
>>> 
>>> # Pass in a last as positional args
... rpc_command('pythagorean_theorum', *[1, 2, 3])
3.7416573867739413
>>> 
>>> # Try a non-existent function
... rpc_command('doesntexist', 5, 6)
Traceback (most recent call last):
  File "<stdin>", line 2, in <module>
  File "<stdin>", line 6, in rpc_command
NotImplementedError: function not found: doesntexist