How open Windows Explorer as different user in Windows 10?

There's probably a better way to do it but if you go to c:\windows, find explorer.exe, Shift+right click and the option "Run as different user" will be there.

All the answers above are wrong (sorry)...

This process will enable what you are after:

1.Take ownership of reg key HK_CLASSES_ROOT\AppID{CDCBCFCA-3CDC-436f-A4E2-0E02075250C2}, and grant yourself Full Control. This key controls how explorer is allowed to launch

  1. Rename the subkey from "runas" to "_runas". If you receive an error doing this, then you probably didn't complete step one correctly.

Now try a runas on explorer.exe and it should run as your alternate user.