How do I perform low level I/O on a Linux device file in Python?

Add an os.lseek() to seek back to the beginning of the string you wrote. Currently you wrote 16 bytes which advanced the pointer. When you read, you start reading at the current pointer so you need to back it up to the start of what you wrote.

This worked for me:

#!/usr/bin/python
import os

data = "xxxxxxxxxxxxxxxx"
dev = os.open("/dev/sdp1", os.O_RDWR)
os.write(dev,data)
os.lseek(dev,0,os.SEEK_SET)
print os.read(dev,16)

According to the os.write documentation:

Note: This function is intended for low-level I/O and must be applied to a file descriptor as returned by os.open() or pipe(). To write a “file object” returned by the built-in function open() or by popen() or fdopen(), or sys.stdout or sys.stderr, use its write() method.

You shouldn't be mixing and matching here. If you use the global function open() to open a file, then you must only use the file object's read() and write() methods. Conversely, if you use os.open() to open a file, then you must only use os.read() and os.write().

So, try replacing your call to open() with os.open(); or, keep the open() call, and replace os.write(dev, ...) with dev.write(...) and replace os.read(dev, ...) with dev.read(...).