how can i query data filtered by a JSON Column in SQLAlchemy?

According to the documentation, it can be done using cast:

from sqlalchemy.types import Unicode

Custom.query.filter(['value'].astext.cast(Unicode) == "what I want")

Assuming that your table is name "custom" and your json field is named "data" the following sql statement will get your results where the value subfield is equal to "what I want".

sql = text("select * from custom where data->>'value'= 'what I want'")
result = db.engine.execute(sql)