Everytime I close Chrome my external mouse stops responding

I figured out a solution. I had Logitech Control Center installed, and it appears that something in either OSX or Chrome changed and broke some kind of interaction between LCC and Chrome (I had not updated LCC previous to this issue). When this began happening the first thing I did was install the latest version of LCC for El Capitan, but that did not fix the problem.

After posting this thread I decided to see how to completely remove LCC and fortunately it ships with an uninstaller. As soon as LCC was uninstalled, I could close Chrome and my mouse kept working. I then reinstalled LCC and could still close Chrome. Guess it got into some kind of bad state and only uninstalling first could fix it.

Using the LCC uninstaller:

  1. Go to Applications > Utilities
  2. Run LCC Uninstaller.app
  3. Restart computer (this step is probably optional but couldn't hurt)

I had the EXACT same issue - I kid you not. Every time I quit out of Chrome, my mouse was dead. I'd unplug and replug the little receiver and it would come back to life - every time 100% repeatable. The solution? UPGRADE LOGITECH CONTROL CENTER software. I was running 10.10.x and had Version 3.6 of the LCC. I upgraded to 3.9.4 and everything is working well now. Did this work for you? You have to download the program manually from logitech then install it and restart.