Disable :hover on click

Option 1. The Javascript solution

Simply add a class prohibiting the application of hover styling on click:

$('div').on('click', function() { // when you click the div
  $(this).addClass('no-hover'); // add the class 'no-hover'
});

div {
  color: blue;
}
div:not(.no-hover):hover { /* only apply hover styling when the div does not have the class 'no-hover' */
  color: red;
}

<script src="https://ajax.googleapis.com/ajax/libs/jquery/2.1.1/jquery.min.js"></script>
<div>hover!</div>

Alternatively, in pure CSS (although without rule persistence)

div {
  color: blue;
}
div:not(:focus):hover {
  color: red;
}
div:focus {
  outline: none;
}

<div tabindex="0">hover!</div>

All you need is this:

$('[your selector]').css({'pointer-events': 'none'})