Debugging not hit breakpoints in .NET CORE MVC 6 application

actually your screen shot was not the debug output, it was the build output.

If you disable the "Enable Just My Code", and enable/disable the Microsoft symbols Server under TOOLs->Options->Debugging->Symbols, and then debug your app after you re-open it, how about the result?

If I create a new app, the breakpoint was hit normally, if I re-open the solution, actually it still could hit the breakpoint, but it is very slow. Like the screen shot 1, if you visit the "debug" output window, it would list the symbols loaded one by one, after about 1min, it would hit the breakpoint like screen shot 2. Of course, I enabled the Microsoft symbols under TOOLS->Options->Debugging->Symbols and disabled the Enable Just My Code for the above steps.

So for your issue, one possible reason is that it just loads the symbols slowly, just wait for a moment.

While Jack Zhai-MSFT's solution worked I still had some weird behavior: breakpoints were working partially. Found solution here that works perfectly: Breakpoint Failed to Bind - Visual Studio 2015 While the above link is loaded with tons of solutions in my case changing configuration from Release to Debug under Build menu Configuration Manager solved all my breakpoints related problems.