"Communication with the Mass Effect 2 server was interrupted or has timed out" error?

The unofficial Binkw32 proxy DLL patcher enables all DLC regardless of whether the connection to Cerberus Network succeeds or fails.

Don't forget to use Windows firewall (or whatever you prefer) to prevent Mass Effect 2 from using the internet. If Origin or Steam interfere and try to "fix" the game files, don't use them, run the game directly using a shortcut to the exe file.

Unfortunately EA is not interested in fixing issues with Mass Effect 2, even if you wanted to pay the ludicrous prices of the DLC for this game (when it obviously should include all DLC by now).

If after installing the new binkw32.dll, the game fails to start, giving an error like "binkw32.dll is either not designed to run on Windows or it contains an error", try the gcc compiled version instead.

The error message will still appear, but it won't affect your ability to use your DLC (regardless of where you got it from - disc/Origin/EA/etc).

Note: Using the command line parameter that skips the intro logo videos seems to make the warning message disappear faster:

-nomoviestartup