Change tmux prefix control keyboard shortcut to alt keyboard shortcut

Yes. See for example this link:

set-option -g prefix M-b

Just extracted the link answered by @Lars Kotthof

Changing tmux prefix to Alt+b:

set-option -g prefix M-b

As other have noted, you can do this by describing your favorite control sequence in e.g. the ~/.tmux.conf config file.

set-option -g prefix M-b

You can also execute this from within tmux by using the command-prompt command, ie. the current prefix and the : character, to run the set-option command interactively. I.e., type Ctrl-b then these characters, as is:

:set-option -g prefix M-b

followed by the Enter key