CefSharp Inject Javascript prior to any document load/processing

Well your answer is correct that you should override the implementation of GetResourceResponseFilter but in case you didn't implement the interface in a correct way you will end up with browser not rendering content, you can instead inherit the DefaultRequestHandler and override the GetResourceResponseFilter() and provide the custom filter as mentioned in the accepted answer, this will be easier in case you need only to ovveride this specific functionality :

public class CustomRequestHandler : DefaultRequestHandler
{
    string script = "alert('hello');";

    public override IResponseFilter GetResourceResponseFilter(CefSharp.IWebBrowser browserControl, IBrowser browser, IFrame frame, IRequest request, IResponse response)
    {
        if (frame.IsMain && request.ResourceType == ResourceType.MainFrame)
        {
            return new JavascriptInjectionFilter(script);
        }
        return null;
    }
}

Then assign it to the chromium browser:

CustomRequestHandler customRequestHandler = new CustomRequestHandler();
chromeBrowser.RequestHandler = customRequestHandler ;

Finally got back to this. Heavily based on example found in: CefSharp.Example/Filters/FindReplaceResponseFilter.cs

implementing the IRequestHandler and IResponseFilter interfaces:

==MainWindow.xaml==

<Window x:Class="ExampleCefSharp001.MainWindow"
  xmlns="http://schemas.microsoft.com/winfx/2006/xaml/presentation"
  xmlns:cefSharp="clr-namespace:CefSharp.Wpf;assembly=CefSharp.Wpf"
  xmlns:x="http://schemas.microsoft.com/winfx/2006/xaml"
  xmlns:d="http://schemas.microsoft.com/expression/blend/2008"
  xmlns:mc="http://schemas.openxmlformats.org/markup-compatibility/2006"
  xmlns:local="clr-namespace:ExampleCefSharp001"
  mc:Ignorable="d"
  Title="MainWindow" Height="1000" Width="1100">
  <Grid>
    <cefSharp:ChromiumWebBrowser x:Name="uiWebView"></cefSharp:ChromiumWebBrowser>
  </Grid>
</Window>

==MainWindow.xaml.cs==

public partial class MainWindow : Window
{
  JavascriptManager jsmanager;

  public MainWindow()
  {
    InitializeComponent();

    jsmanager = new JavascriptManager(uiWebView);
  }
}

public class JavascriptManager : IRequestHandler
{
  string injection = "window.InjectedObject = {};";

  public JavascriptManager(ChromiumWebBrowser browser)
  {
    browser.RequestHandler = this;

    //  Lets just pretend this is a real url with the example html above.
    browser.Address = "https://www.example.com/timingtest.htm"
  }

  public IResponseFilter GetResourceResponseFilter(IWebBrowser browserControl, IBrowser browser, IFrame frame, IRequest request, IResponse response)
    {
        if (frame.IsMain && request.ResourceType == ResourceType.MainFrame) 
        {
            return new JavascriptInjectionFilter(injection);
        }
        return null;
    }
}

public class JavascriptInjectionFilter : IResponseFilter
{
    /// <summary>
    /// Location to insert the javascript
    /// </summary>
    public enum Locations
    {
        /// <summary>
        /// Insert Javascript at the top of the header element
        /// </summary>
        head,
        /// <summary>
        /// Insert Javascript at the top of the body element
        /// </summary>
        body
    }

    string injection;
    string location;
    int offset = 0;
    List<byte> overflow = new List<byte>();

    /// <summary>
    /// Constructor
    /// </summary>
    /// <param name="injection"></param>
    /// <param name="location"></param>
    public JavascriptInjectionFilter(string injection, Locations location = Locations.head)
    {
        this.injection = "<script>" + injection + "</script>";
        switch (location)
        {
            case Locations.head:
                this.location = "<head>";
                break;

            case Locations.body:
                this.location = "<body>";
                break;

            default:
                this.location = "<head>";
                break;
        }
    }

    /// <summary>
    /// Disposal
    /// </summary>
    public void Dispose()
    {
        //
    }

    /// <summary>
    /// Filter Processing...  handles the injection
    /// </summary>
    /// <param name="dataIn"></param>
    /// <param name="dataInRead"></param>
    /// <param name="dataOut"></param>
    /// <param name="dataOutWritten"></param>
    /// <returns></returns>
    public FilterStatus Filter(Stream dataIn, out long dataInRead, Stream dataOut, out long dataOutWritten)
    {
        dataInRead = dataIn == null ? 0 : dataIn.Length;
        dataOutWritten = 0;

        if (overflow.Count > 0)
        {
            var buffersize = Math.Min(overflow.Count, (int)dataOut.Length);
            dataOut.Write(overflow.ToArray(), 0, buffersize);
            dataOutWritten += buffersize;

            if (buffersize < overflow.Count)
            {
                overflow.RemoveRange(0, buffersize - 1);
            }
            else
            {
                overflow.Clear();
            }
        }


        for (var i = 0; i < dataInRead; ++i)
        {
            var readbyte = (byte)dataIn.ReadByte();
            var readchar = Convert.ToChar(readbyte);
            var buffersize = dataOut.Length - dataOutWritten;

            if (buffersize > 0)
            {
                dataOut.WriteByte(readbyte);
                dataOutWritten++;
            }
            else
            {
                overflow.Add(readbyte);
            }

            if (char.ToLower(readchar) == location[offset])
            {
                offset++;
                if (offset >= location.Length)
                {
                    offset = 0;
                    buffersize = Math.Min(injection.Length, dataOut.Length - dataOutWritten);

                    if (buffersize > 0)
                    {
                        var data = Encoding.UTF8.GetBytes(injection);
                        dataOut.Write(data, 0, (int)buffersize);
                        dataOutWritten += buffersize;
                    }

                    if (buffersize < injection.Length)
                    {
                        var remaining = injection.Substring((int)buffersize, (int)(injection.Length - buffersize));
                        overflow.AddRange(Encoding.UTF8.GetBytes(remaining));
                    }

                }
            }
            else
            {
                offset = 0;
            }

        }

        if (overflow.Count > 0 || offset > 0)
        {
            return FilterStatus.NeedMoreData;
        }

        return FilterStatus.Done;
    }

    /// <summary>
    /// Initialization
    /// </summary>
    /// <returns></returns>
    public bool InitFilter()
    {
        return true;
    }

}

Thanks to amaitland for pointing me in the right direction, and for the sample program that the vast majority of the above code was based on. End result:

<html><head></head><body><script>window.InjectedObject = {}</script>
  <script>
    isObjectPresent = typeof InjectedObject == "object";
  </script>
  <p>isObjectPresent?</p>
  <div id="result"></div>
  <script>
    document.getElementById("result").innerHTML = isObjectPresent;
  </script>
</body></html>

Which meets my needs of pre-processing the document with some text at the top of the header ensuring no timing issues where existing code might be run before the injected code.

edit couple small fixes. added control logic to only insert when a mainframe is loaded.