Are algebraic varieties strictly more general than (differentiable) manifolds?

The classes of varieties and manifolds have nontrivial intersection, but neither one contains the other. A complex projective variety can have singularities which would disqualify it from being a complex manifold. If it is nonsingular, then using the Jacobian criterion we see that we get a complex manifold. For the converse, if we can holomorphically embed our manifold in $\Bbb{P}^n$ as a closed subset then by Chow's Lemma it can be given the structure of an algebraic variety.

Of course, there are complex manifolds that are not algebraic. For instance the Hopf Surfaces $(\Bbb{C}^2\setminus \{0\})/\Gamma$ with $\Gamma$ a discrete group acting freely admit no Kähler metric and cannot be projective.

Actually, Serre's GAGA paper gives a way to translate between analytic geometry and algebraic geometry in the complex case. However, the suitable "analytic" notion of algebraic variety is an "analytic space" which is like a complex manifold but allowing for singularities.

Once we stop working over $\Bbb{C}$, we notice that algebraic varieties make sense over any field $k$ whereas the notion of manifold pretty much needs one to use $\Bbb{R}$ or $\Bbb{C}$. (Apparently there are analogues of manifolds over $\Bbb{Q}_p$ but I don't know much about that.) So, the notion of variety is much more general in that being cut out by polynomial equations makes sense over any ring let alone a field; varieties are more "algebraically general" whereas manifolds are more general in that over $\Bbb{R}$ and $\Bbb{C}$ there are many functions that are smooth/holomorphic but not polynomial.

Another useful piece of the story is the Kähler group problem: which finitely presented groups arise as fundamental groups of Kähler manifolds? Smooth projective varieties are Kähler manifolds, and I believe there are no known properties of fundamental groups that distinguish these classes. On the other hand, any finitely presented group arises as the fundamental group of a compact complex manifold, so the Kähler condition is crucial.